Gilbert's Syndrome
- mild (unconjugated) hyperbilirubinaemia
- normal LTFs
- no bilirubinuria
- no haemolysis
Post-Operative Jaundice
- pre-hepatic
- transfusion related
- free-Hb, incompatability, mechanical damage
- old / out-of-date, incorrectly stored blood
- resorption of haematoma
- hepatic
- congenital
- Gilbert's (ligandin deficiency → ↓uptake)
- Crigler-Najjar (Type 2 - ↓glucuronyl-transferase)
- Rotor and Dubin-Johnson (↓ biliary excretion)
- drug-induced
- halothane, enflurane
- flucloxacillin, rifampicin, isoniazid
- methyl-dopa, paracetamol
- infective hepatitis, septicaemia
- hypovolaemia, hypotension, hypoxia
- hepatic ischaemia/hypoxia
- toxins
- trauma
- post-hepatic
- bile duct trauma, oedema, ligation
- cholangitis
- cholelithiasis, stones
- pancreatic / ductal carcinoma
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