Metastatic Prostate Cancer
- isolated ↑↑ALP:
- ∝ liver, lung, bone, intestine, placenta
- normal LFTs, ∴ unlikely hepatic origin
- Paget's or bony 2°s most likely
→ prostate, breast, lung, thyroid, kidney, adrenal
- multiple myeloma less likely → ALP usually mild/normal & Ca++ elevated
- *marked elevation of PSA
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