Isolated ALP Rise - Paget's Disease
- ALP ∝ bone, hepatobiliary, gut, lung, placenta
- normal LFTs → hepatobiliary cause unlikely
- bone secondaries can also result in isolated ALP rise
→ prostate, breast, lung, thyroid, kidney
- multiple myeloma doesn't usually result in isolated ALP rise
→ gammopathy & ↑Ca++
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